ACB 330 Lecture Notes - Lecture 12: Notochord, 2-Step Garage, Neural Tube
29 Mar 2018
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Document Summary
Embryo can regulate to compensate for removed blastomeres. Isolated blastomere may regulate to form whole embryos. Determination of a cell is independent of other cells. Are segregated during blastomere cleavage determines program of zygotic gene activation. Blastomeres form the same tissues in isolation as they do in intact embryos. 2 components: inducer tissue release inducing stimulus, diffusible molecule, extracellular matrix macromolecule, direct cell contact, competent responding tissue. Reacts to inducing stimuli with specific developmental response. Presumptive epidermis loses its ability to respond to the inductive signals from dorsal lip. Can gain competence: neurula stage can gain ability to response to signals. Commitment is a 2-step process: cell becomes specified, cell is determined when that fate irreversible. End result is a specialized and differentiated cell. Specification of fate requires an induction from p2. Binds to receptor mom5 on the ems blastomere. Inducing the e blastomere to form intestine endoderm. Mom2 signal causes differential accumulation of the tf pop1.
