ACB 330 Lecture Notes - Lecture 20: Intermediate Mesoderm, Mesoderm, Notochord

• School: U of S
• Department: Anatomy and Cell Biology
• Course: ACB 330
• Professor: Kulyk William

Document Summary

Implant cells secrete noggin (bmp inhibitor) into intermediate mesoderm. Types of mesoderm: paraxial, intermediate and lateral plate and chordamesoderm (most medial). Lateral: splits into somatic (top, curls out/down) and splanchnic (bottom, wraps notochord) Start off continuous, lay latera to notochord and neural tube. Segmentation clock using oscillating waves of gene expression. (cid:272)y(cid:272)i(cid:272) a(cid:272)ti(cid:448)ation/dea(cid:272)ti. of (cid:862)not(cid:272)h(cid:863) signaling at (cid:272)ell surfa(cid:272)e. Mutations in these type of signalling ligands can lead to deadly scoliosis. Involves segmentation of this layer of mesoderm and a mesenchymal-epithelial transition cells can switch mesen to epith. Fgf and wnt which are released from posterior end. Separation of somite blocks happen at boundary points: These cells express ephrin on surface and nearby posterior cells express eph, is below the separation cute. Shh from notochord pax1 in ventralmedial potion of somite. These cells then undergo epi mesenc transition and leave somite, they then condense around notochord and neural tube to form vertebrae.