ACB 330 Lecture Notes - Lecture 22: Zone Of Polarizing Activity, Fgf10, T-Box
5 Apr 2018
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Limbs made from somatic mesoderm cartilage/bone and ct or somite mesoderm limb muscles. And mesoderm limb buds. (cid:862)fgf-(cid:1005)(cid:1004)(cid:863): i(cid:374)du(cid:272)es o(cid:448)e(cid:396)lyi(cid:374)g li(cid:373)(cid:271) ectoderm to form aer. Aer then secretes fgf-8 this maintains proliferation of mesoderm cells beneath it. Also stops cells from turning into cartilage too quickly. * with non limb mesoderm aer degenerates and limb growth stops. If you implant a fgf10 bead at midpoint= fore hind limb. Ant post: controlled by mesoderm signalling with zpa at posterior base. *if you implant zpa on ant= mirror image of limb. Shh signalling inhibits gli3r. creates reverse gradient of this. :hoc 9/10 is most proximal hox 13 is distal. Wnt7a activates lmx1 tf differentiation of dorsal skeletal structures w/o wnt7a ventral tendons develop in both ven/dor halves of foot (cid:396)e(cid:395)ui(cid:396)e apoptosis: fo(cid:396) sepa(cid:396)atio(cid:374) of toes/fi(cid:374)ge(cid:396)s. (cid:862)i(cid:374)te(cid:396)digit (cid:374)e(cid:272)(cid:396)oti(cid:272) zo(cid:374)e(cid:863). Uses bmp"s to do this (cid:862)ge(cid:396)(cid:373)li(cid:374)(cid:863) is bmp i(cid:374)hi(cid:271)ito(cid:396) fo(cid:396) (cid:272)ell death= (cid:272)(cid:396)eates (cid:449)e(cid:271)(cid:271)i(cid:374)gs. This p(cid:396)o(cid:272)ess also (cid:272)(cid:396)eates joi(cid:374)t (cid:272)a(cid:448)ities: (cid:862)gdf-5(cid:863) type of bmp.
