ACB 330 Lecture Notes - Lecture 19: Basic Fibroblast Growth Factor, Myogenin, Myf5
Document Summary
Dermatome: specified in response to inductive signals secreted from dorsal portion of neural tube. : cells migrate out of somites and spread underneath dorsal epidermis to form the dermis of skin in back region. Myotome: form all skeletal muscle fibers of the body along with cranial so(cid:373)ito(cid:373)eres. (cid:862)pa(cid:454)3(cid:863) i(cid:374) dorso(cid:373)edial a(cid:374)d ve(cid:374)trolateral portio(cid:374)s of smite specifies primaxial and abaxial myotome compartments. E(cid:454)pressio(cid:374) of tf (cid:862)m(cid:455)od(cid:863) + (cid:862)m(cid:455)f-5(cid:863) the(cid:374) co(cid:373)(cid:373)its cells to myoblasts lineage. In the head: myoblasts migrate out of the somitomeres form extrinsic eye muscles + muscles of jaw/face and the pharynx/larynx. Urogential ridge is what the nephrogenic cord sits in. Intermediate mesoderm urogenital ridge bifurcates splits a) gondal ridge ovary and testes or b) nephrogenic cord kidneys and ureters. Wnt9b induce adjacent metanephric mesenchyme to form cell aggregates to differentiate into nephrons: bmp4 inhibits branching in proximal stem. Meso ducts turn into vas deferens + epididymis.