ANSC 313 Lecture Notes - Lecture 1: Portuguese Water Dog, Tibetan Terrier, Golden Retriever

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20 Jun 2018
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"Ethical" mate choice !
Example: homozygous dominant lethal!
Chinese crested !ā€¢
Hair missing on much of body!ā—¦
Hairlessness is a homozygous lethal!ā—¦
pp= powder puļ¬€!ā—¦
Pp= !ā—¦
PP= lethal !ā—¦
!
Examination of parents must be through because of complete penetrance and variable expressivity!
!
Autosomal!
Resistive!ā€¢
Dominant!ā€¢
But sometimes more than two alleles!ā€¢
!
Dominance hierarchy of alleles!
!
!
Also co-dominance when heterozygous has a diļ¬€erent phenotype reduced then either ā€¢
homozygous !
Example: all these horses are e/e at MC1R so no black on them, see hand out for eļ¬€ects ā—¦
with E !
Can breed horses to get diļ¬€erent kinds that are wanted not always best to best ā€£
breeding!
Example: coat colour Merle !ā—¦
Is a heterozygous condition!ā€£
Not completely healthy ?!ā€£
More then one colour in the iris of the eye in heterozygous !ā€£
In humans it is classiļ¬ed a disorder but in dogs its unsure!ā€£
Believed dogs might not have perfect vision!ā€£
If homozygous for this mutation then most of the coat colour is gone from the fur and ā€£
almost totally deaf and tiny eyes that are not able to have vision!
!
Autosomal recessive generalization !
Most enzyme deļ¬ciencies ( inborn errors in metabolism)!ā€¢
Phenotype is consistent!ā€¢
Symptoms often severe!ā€¢
Consanguinity is common ( shared blood- relatedness)!ā€¢
Parents are related !ā—¦
!
Many diseases are called autosomal recessive because neither parents look aļ¬€ected!
Better proof: recessive X recessive =100% recessive oļ¬€spring!
%breed two together to see if all oļ¬€ spring have recessive !
Such breeding is often not possible!
!
Most enzymes deļ¬ciencies!
Portuguese Water Dog!ā€¢
Tibetan terrier!ā€¢
Most breeds have some recessive disorders!ā€¢
Golden retriever !ā€¢
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Document Summary

Hairlessness is a homozygous lethal pp= powder pu . Examination of parents must be through because of complete penetrance and variable expressivity. Also co-dominance when heterozygous has a di erent phenotype reduced then either homozygous. Example: all these horses are e/e at mc1r so no black on them, see hand out for e ects with e. Can breed horses to get di erent kinds that are wanted not always best to best breeding. More then one colour in the iris of the eye in heterozygous. In humans it is classi ed a disorder but in dogs its unsure. If homozygous for this mutation then most of the coat colour is gone from the fur and almost totally deaf and tiny eyes that are not able to have vision. Most enzyme de ciencies ( inborn errors in metabolism) Many diseases are called autosomal recessive because neither parents look a ected.

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