ANSC 460.3 Lecture Notes - Lecture 8: Choline, Ketone Bodies, Niacin
27 Jun 2018
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FLS
-Accumulation of fat in cows liver
-Rate of TG synthesis is greater than TG export as VLDL
-Impairs liver function
oGluconeogenesis, ureagenesis impaired
-Fat stored reduced when in positive energy balance
-very little absorption of glucose from the intestine so produce it through gluconeogenesis which
mostly occurs in the liver
-liver also detoxifies ammonia into urea
othis diminished and can cause urea toxicity
Symptoms of FLS
-symptoms similar to ketosis
oelevated blood and urine ketones
-fat infiltration of liver and also more TG in the liver
-impaired liver function
olow blood glucose and high blood NH3
consequences of FLS on immune function
-impaired immune function because impaired function of the liver
oenergy deficiency
immune cell impairment
ohepatocyte immune function
-immunosuppression
omastitis, metritis, pneumonia become fatal
-mortality as high as 50%
Treatment of ketosis and FLS
-500ml of dextrose solution orally or intravenously
olast only 2 hours
odextrose rapidly excreted via kidneys
-propylene glycol orally twice daily
oeffective
oabsorbed through rumen and goes into the liver
ogoes into succinal CoA which goes into the krebs cycle
-boost glucose supply
Treatment of FLS
-poor response to treatment
oboost glucose status for mill and moderate FLS
-14 day glucogon infusion
oimpractical
ounlicensed for use in cows
-diagnosis difficult
oliver biopsies or post mortem
-cull cows with sever FLS
find more resources at oneclass.com
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Document Summary
Rate of tg synthesis is greater than tg export as vldl. Treatment of fls poor response to treatment: boost glucose status for mill and moderate fls. 14 day glucogon infusion: impractical, unlicensed for use in cows diagnosis difficult, liver biopsies or post mortem cull cows with sever fls, relapse rate high. Increases tca activity and glucose required in terms of energy metabolism reactions: when providing it it increases kerbs cycle activity which increases the ability of the liver to oxidize nefas monensin supplementation. High nel diets in dry period reduce post-partum dmi and greater bcs loss. Restricting energy intake during dry period leads to better transition success. Metabolic diseases incidence in high-yielding dairy herd can be high occur in early lactation improper feeding is usually the culprit can disrupt promising lactations critical control areas to prevent metabolic diseases prepare rumen for feed changes. Monitor forage quality and nutrient content of feed ingredients.
