BMSC 230 Lecture Notes - Ketose, Hexose, Aldose
12 Oct 2012
School
Department
Course
Professor
Document Summary
High concentration of galactose in the blood: galactosemia. Regulation of the entry and use of glucose resdiues in glycolysis. Low in energy: amp, adp and f2,6p2. High in energy: fatty acids, acetyl-coa and atp. Produces nadph: need for the synthesis of lipids. Produces r5p: need for the synthesis of nucleotides. Max activity of pathway is found where there is maximum amount of lipid synthesis. 1st 3 reactions: irreversible: conversion of g6p to ru5p, produces 2 nadph, reduction of nad to nadph, oxidation of g6p to ru5p. Reactions 1-4 are part of the oxidative pentose phosphate pathway. Reactions 5-8 are part of the non-oxidative pentose phosphate pathway. Every molecule of g6p produces 2 molecules of nadph. Reaction 1: oxidation of g6p at carbon 1. Reaction 2: opening of a ring structure to an open structure. Reaction 3: decarboxylation reaction and oxidation of 6-phosphogluconate at carbon 3. Reaction 4: conversion of ribulose-5-p to ribose-5-p (ketose to aldose)
