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BMSC 230 (6)
Jon Stone (6)

Jan 25- Pentose Phosphate Pathway

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Biomedical Sciences
BMSC 230
Jon Stone

th Jan 25 /11 High concentration of galactose in the blood: galactosemia - Galactose can’t metabolize - Probably high concentration in liver too - Converted to an acidic form Galactose Galactitol (very toxic) Galactitol accumulates in the liver - Tissue (liver) becomes enlarged - Vision impaired - Mental retardation Usually happens in infants - No treatment - Reduce intake of milk Enzyme: uradil transferase found in liver Regulation of the entry and use of glucose resdiues in glycolysis Activate enzyme phosphofructokinase - Low in energy: AMP, ADP and F2,6P 2 Inhibit enzyme phosphofructokinase - High in energy: ATP and citrate Activate enzyme pyruvate kinase - Low in energy: FBP Inhibit enzyme pyruvate kinase - High in energy: fatty acids, Acetyl-CoA and ATP Pentose Phosphate Pathway Three-fold Pathways - 1. Produces NADPH o Need for the synthesis of lipids - 2. Produces R5P o Need for the synthesis of nucleotides - 3. Entry point for dietary pentose sugars Max activity of pathway is found where there is maximum amount of lipid synthesis - Adipose tissue - Mammary glands - Liver - Adrenal glands 8 Reactions of Pathway - 1 3 reactions: irreversible o Conversion of G6P to Ru5P o Produces 2 NADPH o Reduction of NAD to NADPH
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