HSC 350 Lecture Notes - Lecture 9: Amyotrophic Lateral Sclerosis, Synaptic Plasticity, Dopaminergic Cell Groups
Document Summary
Multipotent neural stem cell gives rise to intermediate precursor transit amplifying cell" that divides asymmetrically. After each cell division, a transit amplifying cell gives rise to a postmitotic neuroblast or glioblast, plus another transit amplifying cell that reenters the cell cycle for an additional round of asymmetric division. Migration: immature neurons migrate a short distance into the granule cell layer. Immature neurons extend their axonal projections along mossy fiber pathways to the ca3 pyramidal cell layer. Send their dendrites in the opposite direction toward the molecular layer. New granule neurons receive inputs from the entorhinal cortex and send outputs to the ca3 and hilus regions. Stem cells growth can be experimented to produce specific dopamine or other type of cell in the body. Transplantation of neurons or their progenitors can replace lost neurons. Embryonic stem cells (es cells) derived from early blastocyst stage embryos can give rise to all cells of the body.
