MCIM 224 Lecture Notes - Lecture 7: Dermatophyte, Malaria, Metronidazole
10 May 2016
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Contains ergosterol (bacteria do not contain sterols; membranes contain cholesterol) mammalian b) cell wall . Rigid, multi-layered, consisting of chitin (polymer of linked n-acetylglucosamine) Reproduce via a spore stage (not same as bacterial spores) Note: dimorphic fungi can switch from yeast mold form. Environment dependent (temperature, nutrients, etc. ) eg. histoplasma mycelial growth at 25 c; yeast growth at 37 c. Mostly in soil (decomposition of organic matter) Allergic response to fungal spores or metabolites. Normal air averages 105 fungal spores / m3. After consumption of fungal metabolic products eg. ergot (an alkaloid chemical) - produced by claviceps mold when grown on rye grains. Growth of fungus in or on a host (ie. an infection) Classified according to the type of tissue initially affected. Outermost layers of skin (epidermis), hair, nails, etc. Caused by dermatophytes (use keratin as nutrient source) eg. trichophyton athlete"s foot. Infections of dermis of skin & subcutaneous tissues. Usually associated with traumatic injury c) systemic (deep)
