MCIM 224 Lecture Notes - Lecture 11: Bloodborne, Marburg Virus, Zoonosis
10 May 2016
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Document Summary
Human papilloma virus: gastrointestinal viruses, viruses of the central nervous system, blood-borne viruses, respiratory viruses, emerging viral diseases. Viruses which replicate in cells of any part of the respiratory tract (upper airways, nasal passages lower bronchioles in lungs) Includes more than 200 different viruses, ranging in severity; Enveloped rna virus with a segmented genome (8 separate & distinct pieces of nucleic acid ) Two types of spike proteins on envelope. Degrades mucus that lines epithelial cells of respiratory tract (allows virus to reach cell surface) Also req. for release of mature virus from the host cell (helps virus separate from host cell envelope) Most common type (responsible for global epidemics) Numerous sub-types and variants (strains) which differ in amino and n spike proteins acid structure of the h. Presently 18 different h types + 11 different n types. Less common & usually milder symptoms vs. Limited host range (humans & seals only) Type a, but instead divided into two main.
