MCIM 309 Lecture Notes - Lecture 8: Immunoglobulin G, Lymphocytosis, Hyperplasia
24 Feb 2017
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Document Summary
Released via exocytosis, cell lysis and cell-cell bridges. Can cause lytic, persistent, latent and even immortalizing infections. Sensitive to acids, solvents detergents and drying. Hhv-1: simplex type 1, mucoepithelial, close contact. Hhv-2: simplex type 2, mucoepithelial, close contact. Hhv-3: varicella -zoster, mucoepithelial & t cells, respiratory and close contact. Hhv-4: epstein-barr, b cells and epithelial, saliva. Hhv-8: kaposi sarcoma, lymphocytes, closet contact. Hhv-5: cytomegalovirus, monocytes, granulocytes, close contact transfusions. Hhv-6: herpes lymphotroptic virus, lymphocytes, salvia. Immediate early proteins regulation of gene transcription: early proteins t. f and enzymes, late proteins --- structural proteins, ends in latent, persistent of latent infection. Reactivated due to stress or immune suppression. Cd8 t cells & ifn-y are important to maintain latency. Must have th1 and cd8 killer t cells to kill infected cells and resolve infection. At risk: children, sexually activate people, physicans/nurses. Incubation: tender lymph nodes, pain, itching, fever, vesicle, wet ulcer, crust, healing. Diagnosis: tzanck smear (microscopy, culture, dna map/pcr for distinction.
