MCIM 321 Lecture Notes - Lecture 5: Phagocytosis, F1 Hybrid, List Of Breaking Bad And Better Call Saul Characters

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Constant and variable regions and domain structure of. Hilschmann and craig were the first to sequence light (kappa) chains from myeloma proteins. This pattern defined the variable and constant regions. It immediately suggested a relationship between structure and function: the variable region was used to recognize different antigens, and the constant region to activate effector mechanisms such as complement. There are striking similarities in the pattern of disulphide bonds and the amino-acid sequence between the different stretches of 110 amino acids, suggesting that they are evolutionarily related, and that they fold up into similar three dimensional structures. Each stretch is folded up into what has come to be called a. Different heavy chains have either 4 or 5 domains. Light chains have two domains, designated vl (variable light) and cl (constant light), and the heavy chains have domains vh, ch1,ch2,ch4. This region is relatively susceptible to attack by some enzymes such as papain.

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