MCIM 321 Lecture Notes - Lecture 15: Macrophage, Precipitin, Selectable Marker

• School: U of S
• Department: Microbiology and Immunology
• Course: MCIM 321
• Professor: Bretscher Peter

Document Summary

The nature and role of mhc antigens: serology, the genetic map of the major. Histocompatibility complex (mhc), mhc-restriction, and the generation and use of congenic, transgenic and gene knock-out mice. We have already seen that skin graft rejection between mhc-disparate individuals is usually due to a cell-mediated response against mhc antigens. Immunization between h-2 disparate mice usually often results in the induction of both a cell-mediated and an antibody response, and the antibodies produced have facilitated the analysis of the molecular features of. We have seen how we can employ antibodies to define idiotypic, allotypic and class- specific epitopes on ig molecules, and how such antibodies can be used to detect these epitopes and thus to reveal the rules governing their inheritance. Similarly, antisera able to recognize histocompatibility antigens can be used to study and detect these antigens and to discern the rules governing their inheritance.