PATH 205.3 Lecture Notes - Lecture 20: Cervical Intraepithelial Neoplasia, Dysfunctional Uterine Bleeding, Uterine Fibroid
Document Summary
Peritoneal lining covers only part of the bladder. Disease can spread easily b/w the bladder and the uterus/vagina as there is nothing separating them. Fsh ovary stimulates development of ovarian follicle. Lh ovary stimulates ovulation from follicle. Fsh ovary estrogen endometrium proliferation of glands (primed for implantation) Lh ovary progesterone endometrium prepares endometrium for implantation. Hormonal disorders: dysfunctional uterine bleeding (dub) Genital neoplasia: fibroids, endometrial disease, cervical disease, uterine fibroids a. k. a. Endometrial hyperplasia = excess of estrogen (unopposed estrogen) for prolonged periods of time. Causes: anovulatory cycles around menopause, exogenous estrogen, polycystic ovarian disease. Can be treated w/ preogesterone: complex with atypia, precursor to endometrioid carcinoma (20-25% risk) Two types: endometrioid carcinoma = arises in a background of hyperplasia (complex w/ atypia, estrogen dependent, this is better than the serous carcinoma, epidemiology: age 55-65, risk factors, obesity, diabetes, hypertension. Infertility: serous carcinoma = arises in a background of atrophic endometrium, estrogen independent, p53 mutation, high grade patients do poorly.