PHPY 304 Lecture 2: ANS 1

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Recite the origin of the sympathetic and parasympathetic system from the central nervous system (e. g. cranio-sacral, or thoraco-lumbar) List the synapses at which acetylcholine (ach) and norepinephrine (ne) are released (slide # 6 and 7) Recite the neurotransmitters (and their proportion) released from the adrenal medulla, and their clinical significance. Recite the precursors for the synthesis of ach, ne and epinephrine: describe the concept of dominant tone. Originate from medulla and sacral spinal cord. Synthesis: from choline and acetyl a, botulism toxin blocks ach release causing paralysis. Preganglionic sympa @ ganglion and synapses at medulla. Synthesis: tyrosine dopa dopamine norepi epi. Releases ach and ne (20%) and epi (80%) Tumors can cause and increase in this release and increase bp. Into circulation when stimulated by preganglionic sympa nerves. Muscarinic: m1, m2, m3, m4, m5. Which branch of ans is innervating the muscle the most. Drugs effecting that system will show a more profound effect.

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