PHPY 304 Lecture Notes - Lecture 5: Neuromuscular-Blocking Drug, Acetylcholinesterase Inhibitor, Neuromuscular Junction
Document Summary
Objectives: describe the pharmacological actions, major side effects and main clinical uses of drugs that mimic, block or modulate the actions of autonomic nervous system neurotransmitters. Mimicked by: m- agonists, acetylcholinesterase inhibitors. Blocker by: m-antagonists, skeletal muscular junction blockers. Uses of the parasympathometrics: reduce intraocular pressure in glaucoma. Ach is only active for a few milliseconds in the synapse before ache metabolizes it. This is one of the fastest known reactions. These drugs increase duration of ach in the synapse. Compounds that bind produce one of 3 reactions: acetylation. Recovers in 3-4 hours: the above two increase cholinergic effects as drugs where it is currently decreased/lacking, phosphorylation. Uses: stop motion sickness (m1, examine the retina. Ibs: acid reflux, 4 major symptoms of urinary incontinence, treat copd, parkinson"s. Side effects: urinary retention, tachycardia, dry mouth, blurred vision. Competitive: antagonize ach at nicotinic recpetors, flaccid paralysis, motor weakness, starts small muscles are works towards large, side effects.