PHPY 304 Lecture Notes - Lecture 7: Ototoxicity, Syndrome Of Inappropriate Antidiuretic Hormone Secretion, Aquaporin
2 Dec 2016
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Document Summary
*major ion channels and transporters on renal epithelial membrane. *identify the sites of action of diuretics in the nephron and their relative diuretic potency. *know the mechanism of action of diuretics and their effect on blood electrolytes and ph. *understand the primary therapeutic use of various classes of diuretics. *know the adverse effects unique to certain diuretic classes. *know the rationale for combining a potassium-sparing diuretic with a thiazide or a loop diuretic. Uses: treatment of edema or for mild hypertension. 20% of blood plasma entering kidneys is filtered into bowman capsule. Filtrate: glucose, bicarbonate, amino acids and electrolytes. Action along the nephron insert picture of nephron here. 65% filtrate and 40% na+ is reabsorbed here. Increase water reabsorption: drug target: carbonic anhydrase, acetazolamide. Major site of reabsorption of glucose, bicarbonate, amino acids and electrolytes. Bicarb is mainly absorbed as c02 via carbonic anhydrase. Increased excretion of nahco3 &k: retention of h ions.
