PHPY 304 Lecture Notes - Lecture 8: Histamine, Vascular Smooth Muscle, Autocrine Signalling
2 Dec 2016
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Document Summary
Neural, endocrine, paracrine, autocrine control direct as well as reflexly regulated responses. How a and b agonists control hemodynamic function effects on heart vs. Importance of sympathetic & renin - ang ii system. Identify the components of the renin-angiotensin-aldosterone system (ras or raas) Describe the actions and sites of action of angiotensin ii (ang ii) and aldosterone. Identify therapeutic targets related to the ras system and how ace inhibitors bp. Describe the roles of nitric oxide (no) & endothelin (et-1) in cv regulation. Describe 3 local (intrinsic) control systems: autacoids: histamine, serotonin, pgs. Remote/extrinsic control: blood pressure, blood volume, bp = co x tpr, co = hr x stroke volume, heart in innervated by both sns & pns, blood vessels are done primarily by sns. Leads to decrease in aldo from medulla, which in turn leads to decrease in blood volume/plasma. Vasopressin system: aka: adh, released from posterior pituitary gland, restores plasma volume, by reabsorption of water in kidneys.
