PHPY 304 Lecture Notes - Lecture 9: Hydralazine, Lisinopril, Sodium Nitroprusside
3 Dec 2016
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Some of their adverse effects (aes) of each. Describe the hemodynamic changes (bp, co, tpr) in labile and late phases of hypertension. The role of the kidney in controlling bp & how diuretics potentiate/enhance the action of other anti-hypertensives. Describe the mechanisms of action, adverse effects, major therapeutic consideration for diuretic, 1 blocker, prazosin, calcium. Channel blocker (ccb), drugs targeting the renin-angiotensin aldosterone system (raas) the ace inhibitors and arbs (at1 sel. antagonist). Describe the major compensatory changes that are evoked by each of the antihypertensive group. Drug classes and prototype to consider: thiazide diuretics: hydrochlorothiazide [hctz, 1-adrenergic blocker: atenolol. Increase in sns, raas, kidney water, na+ handling defects. Increase in co is due to increase in plasma volume which is due to increase in renal return, which is due to defective renal handling of sodium and water. Increase in renal sns so trp stays increased.
