TOX 300 Lecture Notes - Lecture 18: Vaginal Cancer, Carcinogen, Metastasis
Document Summary
Classification of the evaluation of carcinogenicity for human beings. Agent is not classifiable as to carcinogenicity to humans. Human and animal data is inadequate (needs more research not enough data) *scientists will never say that a chemical is not carcinogenic there"s a slight possibility that a chemical may be carcinogenic. Most data are from dose-response experiments done on laboratory animals (rats and mice) There are also computer-based approaches that provides some prediction whether the chemical has the potential to cause cancer, teratogenicity, etc. It uses the structure-activity relationships to make this prediction: however, we don"t want to base our risk assessments solely on the computer program. Xenobitoics can get bioactivate into reactive electrophiles (looking for electrons) will bind covalently to molecules (dna, protein, and lipids: polycyclic aromatic hydrocarbons epoxides. Xenobiotics can get involved in redox cycling produces the superoxide anion radical: the superoxide anion radical can be further reduced to hydrogen peroxide, then the hydroxyl radical.
