Class Notes (838,800)
Canada (511,100)
Biology (2,271)
BIOL 130 (308)
Lecture 13

Outline of Lecture 13 Limb Development

1 Page
Unlock Document

BIOL 130
Barry Mc Clinchey

Outline of Lecture 13 Limb Development I. Embryologic origin of the limb - Limb bud appears at 4 weeks and is complete at 8 weeks; limbs rotate during development - Source of limb components (mostly what you’d expect) - Lateral plate mesoderm: bones, tendons, ligaments, dermis, vasculature - Surface ectoderm: epidermis - Neural crest: melanocytes - Neural tube: motor and sensory neurons - Somites of mesoderm: limb muscle - Structure of limb buds - Form from somatic lateral plate mesoderm - Edge of bud is apical ectodermal ridge (AER), critical for limb formation - Within limb bud is progress zone (high proliferation) and mesenchymal mesoderm (stop dividing, differentiate into proper proximal/distal fate) II. How the limb is patterned - Limb axes are unusual: anterior (thumb), dorsal (back of hand), distal (fingers) - FGF expression by the AER controls where the limb forms along the A/P axis of the body A) Proximal/Distal axis - The Hox-d genes are differentially expressed along the P/D axis
More Less

Related notes for BIOL 130

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.