BIOL130 Lecture Notes - Gli3, Repressor, Morphogen

33 views4 pages
Published on 28 Jan 2013
Department
Course
Limb Development
Timeline –
buds appear at 26d – somites 8-12
lower buds at 28d – somites 24-29
complete at 56d
Embryological Origins of limb components:
skin = surface ectoderm
melanocytes = NCC
sensory neurons = NCC
motor neurons = neural tube
myotome (somites) = muscle
somatic lateral plate mesoderm + ectoderm = limb buds
(bones, tendons, ligaments, dermis)
AER – apical ectodermal ridge
divides limb bud into dorsal-ventral
transplanted ectoderm can form new AER
induced by mesenchyme
**both need to be functioning for proper limb-bud development
PROGRESS ZONE – actively dividing cells adjacent to AER
mesenchyme here determines proximal/distal patterning
“rejacketing experiments” – late mesenchyme + early cap
only distal elements form
**age of mesenchyme determines proximal/distal fate**
AER
Progress Zone
Unlock document

This preview shows page 1 of the document.
Unlock all 4 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.