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BIOL239 Lecture Notes - Sickle-Cell Disease, Zygosity, Phenotype

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Christine Dupont

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Lec1: mendelian genetics
15. Phenotype: observable characteristics, introduce generational lines
Cross-fertilize, even self-fertilize
Version or variant of gene
17. for single gene: 2 traits, still there but not expressed
18. Chromosomes from either parent, homologous chromosomes (same gene, same order, not exact
same DNA sequence, diff. alleles but same gene come from diff. dna sequence)
19. italicized means the gene/allele/dna, not protein product
2 chromosomes of pea, diploid; look at texture of pea; 2 copies of dominant allele; phenotype is smooth
Genotype is heterozygous but still smooth, but for homozygous recessive is wrinkled
20. multiple alleles of genes.
Polymorphic: many different versions, how frequent do you see those versions in a population
Monomorphic: many genes in metabolic processes eg. Sickle cell anemia, mutant gene; other versions
are at really low frequency, eg. Tsacs, Huntington
21. genes come in pairs
22. female: homo. Dominant
Male: homo. Recessive
Since both homo.
Punnet squares: possible consequences are all heterozygous; all monohybrids
PS shows possibilities, not all the offsprings, not actual # of babies
24. offspring are all heterozygous, all yellow peas
25. only one option, monohybrids, heterozygous consequences
For both heterozygous, phenotypically: 1:2:1, genotypically: 3:1
29. for texture (SBE1), not in italics, know if talking about gene or protein
If change amino acid sequence, mutate gene and cause inactive SBE1
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