Class Notes (834,627)
Canada (508,661)
Biology (2,253)
BIOL 239 (290)

Pedigree Analysis.docx

2 Pages
Unlock Document

BIOL 239
Heidi Engelhardt

Pedigree Analysis  Pedigree Analysis o Many human traits run in families : most do not show a simple Mendelian pattern of inheritance  Why? Because most are influenced by more than one gene.……multifactorial e.g., eye colour o Most confirmed single-gene traits in people are relatively rare, involving abnormalities that are either disabling or life-threatening o Studying family genetic histories, or pedigrees, gives insight as to how mutant alleles causing abnormalities are inherited o Examples of monomorphic genes with mutant phenotypes showing pleiotropy  Sickle-cell disease  Abnormal hemoglobin, sickle-shaped red cells, anemia, blocked circulation, increased resistance to malaria  Single nucleotide substitution results in incorrect amino acid, resulting in a change in conformation of themβ-globin protein when deoxygenated  Sickle cell anemia is a syndrome: the phenotype varies  Conditions affect expression of the trait  Tay-Sachs disease  Missing enzyme; build-up of fatty deposit in brain;nbuild-up destroys nervous development; blindness, paralysis, mental retardation  Phenylketonuria (PKU)  Mutation in enzyme in metabolic pathway causes the amino acid phenylalanine to bu
More Less

Related notes for BIOL 239

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.