BIOL239 Lecture Notes - Lecture 10: Population Genetics, Allele Frequency, Genotype
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Phenotypic: proportion of individuals in a population with a particular phenotype. Genotypic: proportion of individuals in a population with a particular genotype. Allele: proportion of all copies of a gene in a population that are of a given allele type. P 2 + 2pq + q 2 = 1. Calculating allele frequencies p (a) = (2452 (2) + 45) / 5000 p (a) = 0. 99 q (a) = (3 (2) + 45) / 5000 q (a) = 0. 01 (0. 99) 2 + 2 (0. 99) (0. 01) + (0. 01) 2 = 1. Hardy-weinberg equilibrium (assume the founding generation is in equilibrium) Aa: 2 (0. 99) (0. 01) = 0. 019 aa: (0. 01) 2 = 0. 0001. First generation (expected number of individuals is 2500) Aa: 0. 019 x 2500 = 47. 5 aa: 0. 0001 x 2500 = 0. 25. Since the genotypic frequencies of the first generation are almost identical to the frequencies in the founding population, the founding population is in h-w equilibrium.