BIOL266 Lecture Notes - Lecture 4: Sequence Alignment, Bioinformatics, G1 Phase

• School: University of Waterloo
• Department: Biology
• Course: BIOL266
• Professor: Steve Forsey

Document Summary

Sequence alignment is the identification of residue-residue matches which preserving residue order/sequence. If you add gaps in the sequences, you can properly align the two strands. The gap/dash could mean that there is some mutation (cid:1445)indel(cid:1446) Mutations create the need for the gap; insertion or deletion of what was originally a b". The true alignment of nucleotide or amino acid sequences is one that reflects evolutionary relationship between two or more sequences that descend from a common ancestor (homology) : indicates two amino acids having similarities. These are two types of sequence alignments. Take the entire sequence one and attempt to align it to the entire sequence two; from beginning to end. Problem: only a small region of the gene aligns to another gene. Slight modification of this makes local alignment. Local: stretches of sequence with highest density of matches are aligned. Especially important for genes that are continually changing its sequence. Structure patterns of similar molecules can reconstruct information.