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Lecture 2

Lecture 2 - Nucleic Acid Structure + Hybridization - BIOL308.pdf

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BIOL 308
Bruce Wolff

Lecture 2September1512Nucleic Acid Structure and HybridizationFunctions of DNA3 major functions1Stores information2Replicates Faithfully Be able to be replicated exactly as how it is which provides stabilityMakes it so it is hereditary and makes it so the exact same gene is continued on preservation of the information3Has the ability to mutate which ironically is the opposite of the second characteristic which is keeping it the sameKnown asvariability of the informationcritical dance between stability and variabilityYou need that variability for the organism to be able to adapt to its environmentThe 2 stranded shape relates to the storage of information and the faithful replicationTake a look atHow do these functions of DNA relate to the physical structure What are DNA sequences related to DNA info the importanceFirst things to consider why DNA How did we know it was the first thing to look at It could of potentially been something elseWe can take a look at history1868Miescher used salmon sperm because that was what was readily available toisolate DNA1944Avery MacLeod McCarty showed pathogenic strains are transferred showed that something in DNA can transfer1947Chargaff reportated the qualities of AT and CG in DNA were the same valueAmount of A and T were always proportional to one another and likewise with G to C1952Hershey and Chase Bacteriophage injected only DNAinto cellsUsed to take over the cell to make more bacteria used to replicate itselfThis demonstrated that DNA had enoughknew enough information to take over1953Watson and Crick proposed the model of DNAthe double helix1958Meselson and Stahl established the DNA molecule that supplies necessary information to make the cell what it isCame up with semiconservative DNA replication1965Nirenburg and Lederother scientists the triple code genetic codeby which protein is made from information in DNAFunction 1 Stores InformationGenethe entire DNA sequence necessary for production of proteinRNAThe information needed for this production is carried inby thesequence of basesDNA carries two kinds of informationCoding information information that is transcribed and translatedWhat is needed to code for proteins and different RNAs rRNA tRNA small regulatory RNAsRegulatorysignalsNot just onoff switches but the entire processlac operonDNA stores information which leads to the understanding of the Central Dogma of Molecular Biology NOTES FROM LECTURES Page 1
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