BIOL308 Lecture Notes - Lecture 4: Signal Transduction, Testtube, Morphogenesis
16 Jul 2014
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11 base pairs per turn, turns every 2. 8 nm and is right handed. Bases exhibit a tilt with respect to the helix axis (20 degrees) Dna-rna and rna-rna helices in a test tube. Might exist in vivo as well - locally and temporarily. A-like dna found in formant spores of bacillus. Rosalind franklin focused on this kind of dna, Found in test tubes when very high salt concentration. 12 basepairs per turn, turn every 4. 5nm, therefore tall and skinny; tilt 7 degrees. Role in reulation of gene expression: discovery of proteins with z-dna binding domains. New discovery: z-dna in promoter regions of some genes. Implicated in chromosomal breakages and large scale deletions/rearrangements (in mammals) Some promoters are enriched with c and g doublets, so z dna is involved in regulation of transcription, mostly for these important house keeping genes. If you modify cytosine (addition of methyl = methylated c, then it can come at high humidity and low salt.
