Class Notes (839,460)
Canada (511,348)
Biology (2,271)
BIOL 308 (146)

Lecture 25 - Control of Transcription - BIOL308.pdf

6 Pages

Course Code
BIOL 308
Bruce Wolff

This preview shows pages 1 and half of page 2. Sign up to view the full 6 pages of the document.
Lecture 25How is transcription initiation influencedifferent molecular mechanismsDirect influence of TFs on assembly of initiation complexesreview1TFs help recruitment of GTFsInteractions of TFs with modulator complex coactivators or corepressors each other ligandspromote or prevent binding of GTFsTFs form enhancesomes action from the distance on binding of GTFsTFs cause architectural changes in DNA in order to promote binding of other GTFsPresence and role of insulatorsTFs regulate changes in chromatin structureremodeling and control histone actylation and deacetylationreview2Concentration and activites of TFsare regulated during cell differentiation and in response to hormones and signals from 3other cells cell signalingProtection of active gene promoters from methylation4And methylation of promoters of genes that shouldnt be activeDifferent Molecular Mechanisms for Control of Transcription InitiationDirect influence of TFs on assembly of initiation complexes1Recruitment of GTFsEukaryotes RNAP not directly recruited TFs act through contact with GTFCoActivatorsCertain TFs need their own coactivator proteinProtein which is not in direct contact with DNA but connects TF with GTFsExamplecAMP response element binding protein CREB binds to cAMP response element CRE and activates associated genes by binding to CREB binding protein CBP which interacts with basal complexCBP is not limited to cAMP responsive genesIt has multiple functions eg Has acetyltransferase activityInteractionsIn general TFs interact with each other or ligands those interactions promote or prevent binding of GTFsInteractions involving repressor proteins NOTES FROM LECTURES Page 1
More Less
Unlock Document

Only pages 1 and half of page 2 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.