BIOL341 Lecture 5: Lec 5_BIOL341_Jan 12
17 Jan 2018
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Document Summary
Langerhans cells: activated dendritic cells travel to lymph nodes through blood vessels & lymphatics to present apc"s to. T cells which go to b cell zone. Keratinocytes: joined together tightly by tight junction protein-protein interactions to hold epithelium together & make cytokines for local inflammation. Dermis: connective tissue of mast cells and dendritic cells. 1: sebum: lipids & fatty acids on the skin that provide a waxy barrier as waterproofing & antimicrobial defense (need a membrane) 2: antimicrobial proteins: psoriasin cleaves peptidoglycan and destabilizes microbe membranes. 3: antimicrobial peptides: expressed by epithelial cells and innate immune cells. C: cathelicidin amphipathic down the barrel (hydrophilic charges, hydrophobic membrane), alpha helix. Created from cleavage from a protein which activates its antimicrobial function. Small, cationic, hydrophobic, selective against microbes (gram -/+, yeast, fungi, viruses) Limited mutation to interact with certain pathogen components. One side is charges & the other is hydrophobic (amphipathic when folded) and one of two mechanisms happen.
