BIOL354 Lecture Notes - Lecture 3: Tetraethyllead, Methyl Group, Hard Water

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17 Dec 2015
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Binds to sh groups on proteins, impairing function. More required to impact in hard water than soft. Cu inhibits photosynthesis and respiration at high concentration. Binds to dna between bases, disturbs base pairing. 5ppm shortens life span of rats by 15% 40mg inhaled fatal to humans kidney failure impairs reproduction in rainbow trout and daphnia. Redox reactions the e is able to come from many different organic compounds. Biomolecules) able to move their electron to o2. Pb 2+ -> exists as organo metallic (tetraethyl lead or tetramethyl pb) (metallic is non toxic) Specific site of action alad (heme synthesis) rapidly inhibitied by pb but slowly reversed. Irritability and hyperactivity - painter"s cramp if threshold exceeded. Binds strongly to soils, hard to take up. High [] impaired germination, growth and photosynthesis. Cummulates poison organometallic has a greater uptake organic will be removed to be more toxic. Bind to rbc -> anemia and renal failure (proteinuria)

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