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Lecture 21

BIOL 355 Lecture 21: Lecture 21

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BIOL 355
Dr.Cheryl Duxbury

Lecture 21 Studies of older adults with elevated levels of AGEs are at greater risk of: Cataract formation, Alzheimers disease, osteoarthritis Arterial stiffness and cardiovascular disease Diabetes (hyperglycemia), chronic kidney disease Anemia, poor skeletal muscle strength and physical performance AGEs form crosslinks, increase oxidative stress (free radicals) and upregulate inflammation Proteins most susceptible are those of connective tissue such as elastin and collagen. They are long lived and stiffen tissues that have matrix that are rich in these proteins These include: skeletal muscle, tendons, joints, bone, heart, arteries, lung, skin and lens of eye Biological Mechanisms for harmful effects of AGE crosslinks AGEs affect virtually every tissue in the body Blood vessels Loss of elasticity in blood vessels Collagen increase in blood vessel walls with age (fibrosis) Elastin content decrease Crosslinks of collagen increase stiffness, decrease elasticity Promotes blood vessel rigidity Increase blood pressure, heart works harder AGEs can induce crosslinking of collagen Brain AGEs accumulates in human brain with age Found in neurofibrillary tangles (dead neurons) and senile plaques (found in Alzheimers disease) Elevated levels of CML (major ACE) associated with elderly cognitive impairment and cerebrovascular disease Skin Loss of elastin in skin Decrease flexibility Increase collagen with cross links Decrease elasticity of skin Skin wrinkles and sags Loss of kidney function with age
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