BIOL355 Lecture Notes - Lecture 33: Osteoporosis, Percutaneous Vertebroplasty, Kyphosis
3 Feb 2016
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Document Summary
Estrogen levels ( sensitivity to pth) Begins early and changes ratio of cortical: trabecular bone (teens. Bones susceptible are vertebrae, hips, wrists, shoulder leads to weaker, thinner bones w/ 2 common problems: Breaks in the femur of the hip. Type 2: senile osteoporosis (vitamin d) crush fractures of the vertebrae of the spine. Affects individuals mainly 70s and 80s significant loss of cortical bone over spongy bone. 33% of women and 15% of older man have this. Cumulative loss of cortical bone and ca++ uptake factors involved include calcium, vitamin d, estrogen, and exercise. 60% of all women over age 60 have osteoporosis rate of bone loss drastically after menopause rate is 6x that of males. 20% trabecular bone lost in first 10 yrs after menopause. 2-3x faster than rate of loss before menopause. Very old women only have of trabecular bone. 10% of compact bone lost in first 10 yrs after menopause. 7 out of 8 occur in women.
