BIOL373 Lecture Notes - Lecture 4: Creatinine, Somatic Nervous System, Renal Pelvis

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4 b - reabsorption, secretion & excretion: reabsorption: movement of water/solutes from ltrate back into the blood, occurs throughout the nephron tubules into peritubular capillaries, selective reabsorption of important solutes and water. Hydrostatic pressure is lower in capillaries than in the intersistial uid which drives reabsorption into the capillaries once substances pass the apical and basolateral barriers. Tubular reabsorption: na+ ions are absorbed by primary active transport, electrochemical gradient drives reabsorption of anions, water moves out of the tubules due to osmosis. Active na transport: sodium is reabsorbed across tubular epithelium in the proximal tubule via passive and primary active transport. Enac: epithelial sodium channel found on the apical membrane, facilitates passive diffusion of sodium into the epithelial cell. Na/k atpase: actively transports sodium across the basolateral membrane in exchange for a potassium ion. Na linked reabsorption: secondary active transport of glucose coupled with sodium reabsorption.

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