BIOL373 Lecture Notes - Lecture 1: Walter Bradford Cannon, Extracellular Fluid, Blood Vessel

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What is physiology: lo(cid:374)g a(cid:374)s(cid:449)er: (cid:862)the s(cid:272)ie(cid:374)(cid:272)e of the (cid:373)e(cid:272)ha(cid:374)i(cid:272)al, ph(cid:455)si(cid:272)al, (cid:271)ioele(cid:272)tri(cid:272)al, a(cid:374)d (cid:271)io(cid:272)he(cid:373)i(cid:272)al fu(cid:374)(cid:272)tio(cid:374)s of. i(cid:374) good health, their orga(cid:374)s, a(cid:374)d the (cid:272)ells of (cid:449)hi(cid:272)h the(cid:455) are (cid:272)o(cid:373)posed(cid:863: short a(cid:374)s(cid:449)er: (cid:862)the s(cid:272)ie(cid:374)(cid:272)e of the fu(cid:374)(cid:272)tio(cid:374) of li(cid:448)i(cid:374)g s(cid:455)ste(cid:373)s(cid:863, our u(cid:374)dersta(cid:374)di(cid:374)g of (cid:858)hu(cid:373)a(cid:374)(cid:859) ph(cid:455)siolog(cid:455) is (cid:271)ased o(cid:374) a(cid:374)i(cid:373)al e(cid:454)peri(cid:373)e(cid:374)tatio(cid:374) What it does for homeostasis: e(cid:454)a(cid:373)ples: Homeostasis between cells, not in blood vessel) extracellular fluid) (cid:494)homeo(cid:495) rather than homo similar, though not the same: walter cannon, (cid:883)(cid:890)(cid:889)(cid:883) 1945. Expanded on bernard(cid:495)s concept of homeostasis: nb: remember these names, study of homeostatic mechanisms physiology, failure to compensate for change disease, study of failure to compensate = pathophysiology. Some internal change or external force acting on organism lose homeostasis. Need to detect that change, and ideally fix it. Central mechanisms for monitoring variables and central ways of fixing them. Negative feedback stabilizes variable; if something goes up, it brings it back down to baseline.

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