BIOL442 Lecture Notes - Gram Staining, Tums, Capsid

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A piece of bad news wrapped in protein. Observed in a gram stain and thought to be a gram+ bacterium. Most viruses are in the range of 10-100 nm. Mimivirus = 390 nm; bigger than some bacteria. Same for dna genome (1,181,549 bp; herpes 150,000 bp) Don"t know what it does yet, but abs against it, have been found in pneumonia patients, also patients with rhuematoid arthritis. First discovery of virus particle - 1892 ivanoski (russian) Important to remember that disease caused by viruses were known long before this. Greeks - rabies, egyptians documentation of poliomyelitis, fevers described during early colonization"s of africa. Independently reported same observation, but realized it must be a very small infectious agent. Same year former students of robert koch found foot-and-mouth disease was transmitted by a filterable agent. If toxin, would not get re-infection, effect would be diminished. If replicative agent, would get re-infection, effect would always occur.

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