BIOL442 Lecture Notes - Lecture 11: Complement Membrane Attack Complex, Cell Adhesion Molecule, Cell Envelope
16 Jul 2014
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Document Summary
Most are based on recognition of broad molecular motifs found commonly in pathogens. Pamps: pathogen-associated molecular patterns e. g. , bacterial cell envelope molecules (e. g. , peptidoglycan, mannose) foreign nucleic acid (unmethylated. Can act quickly to rid the infection before adaptive response occurs. Innate mechanisms signal the adaptive response to begin. A sequence of physiologic events triggered by an invading microbe and/or damage to tissue. Brings more blood to site, and thus more defense cells and molecules. Prostaglandins and histamine are important effector molecules of vasodilation (mast cells) Allows extravasation, or movement of cells with immune function out of the blood vessels and into affected tissues. Accompanied by fluid movement into the local tissue. Evidenced by edema (swelling) of the local area. Carries serum components such as antibodies and complement factors into the area. Vasodilations/increased permeability passively bring in cells and serum to site. Inflammation induces the vessel walls (endothelium) to produce surface cell adhesion molecules (cams)
