BIOL444 Lecture Notes - Toxic Shock Syndrome, Coagulase, Glycopeptide Antibiotic

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Set 03 diseases of the skin & soft tissue. Minor skin community: clostridium perfringens: anaerobes, spore former, normally in soil & water, 20% healthy individuals, streptococci @ oral cavity or e. coli & gram due to fecal contamination. Gram + cocci, tetrads & clusters in pure culture, pairs or single in pus, non-motile, facultative anaerobes, salt- tolerant & catalase + (key for identification), optimal temperature ranges from 10-40 c, resist drying. Habitat: skin, mucous membranes (e. g. external nares & vagina: s. aureus found commonly @ nasal carriage: 25% infected, transient (hit & run infections, s. epidermidis found commonly @ skin: catheter infection, opportunists when gets elsewhere. Huge # of s. aureus strains, identification is done by phage typing pattern (groups i to iv). Different strain different toxins due to the specific transducing phage they carry (virulent factor: skin & soft-tissue infections. Abscesses/boils (stye, furuncles, carbuncles) & wound infections. Furuncles: superficial infected hair follicle (no scarring if no squeezing)

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