BIOL444 Lecture Notes - Lecture 1: Flagellin, Gram-Negative Bacteria, Peptidoglycan
10 Dec 2016
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Group 1: bottom line the damage that is seen in meningitidis is due to inflammation. They have pilli or fimbriae that adhere to host epithelial cells; they recognize prr, cell wall components, activate tlr. Results in the transcription of various cytokines (cell signalling molecules eg il-1, interferon gamma). Upon binding of pamps to tlrs, distinct signalling pathways are activated to recruit nf-kb (tfs). Tfs enter nucleus and initiate cytokine genes whose products stimulate and direct immune responses. Major set of genes activated are the type 1 interferon genes or genes encoding pro inflammatory cytokines such as il-1, il-12, tnf-alpha= trigger th1 response: explain why igg made to capsule components (vs. cell wall is protective). Killing of cell by endosomes, which have superoxide, h2o2, hocl.
