GERON255 Lecture Notes - Lecture 16: G0 Phase, G2 Phase, Geron Corporation
19 Apr 2016
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Document Summary
Premise a master clock that regulates longevity is in the hypothalamus. Function to control production of hormones by the pituitary gland. Theory info is carried from hypothalamus throughout the body by neurons and hormones: as we age this ability decreases. Premise aging is a period of the life span and is genetically coded for in the genes. Aging is a period in life stage: major events in life span: Hormones, neurotransmitters, neurons, and enzymes decrease with age. It is said that the death gene is that last one to be turned on. G2 phase = cells prepare for mitosis. G0 phase (not mentioned before) = non-dividing stage. This is a highly regulated event ! Genes that may be involved in the aging process: Fos gene isolated from cancer cells (uncontrolled replication) Fos gene (humans) implicated in norma control of cell cycle: found: Young cells given growth factors produce fos protein.
