GERON255 Lecture Notes - Lecture 25: Varicose Veins, Geron Corporation, Elastin

• School: University of Waterloo
• Department: Gerontology
• Course: GERON255
• Professor: Cheryl Duxbury

Document Summary

Many of these changes in a decrease in the co in limited muscular (cid:1) activity. Loss of elasticity from a decrease in elastin and smooth muscles and more cross-links between collagen fibres. If the walls become too thick there is a reduced diameter inside = peripheral resistance is increased and blood flow is hindered (increase in systolic pressure) Systolic blood pressure increases by 40% in elderly so much that normal is 160mm hg. Arteries become thicker and more rigid and less able to vasodilate and vasoconstrict. Short breath, chronic fatigue, red or pale skin, varicose veins, cold. Heart disease is 4th leading chronic disease for ages 45-64. Still #1 killer for those aged +65. Small tear and the media layer is exposed to blood flow. Body treats like wound, so platelets enter (blood clotting cells) and. Monocytes (wbcs) enter wound and differentiate macrophages when they enter.