GERON255 Lecture Notes - Lecture 20: Lipid Peroxidation, Lipofuscin, Geron Corporation
19 Apr 2016
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Catalase and glutathione reductase: adds a proton and e- back to s-s bond so proteins can be functional again, catalase breaks down h2o2 (toxic) that is converted to h2o and o2 (harmless) Vitamin e: most potent free radical scavenger, lipid soluble vitamin (if needed amount exceeded it is excreted, donates proton and e, known as chainbreaker . It stope peroxidation in membranes, thickening: studies show: vitamin e makes o2 more efficient in the brain heart, organs. 400 iu with 300-600 mg of vitamin c prevents cataracts up to 70% Vitamin c: reducing agent = donates proton and e, decreases risk of cancer, c. v. and cataracts 1000 mg/day, water soluble, found in citrus fruits and vegetables. B-carotene (beta-carotene: precursor of vitamin a, vitamin a in high amounts is toxic to body, carrots ! Theory of free radical damage (cid:1) (cid:1) (cid:1) (cid:1)
