KIN217 Lecture Notes - Lecture 5: Acetyl-Coa, Gluconeogenesis, Phosphofructokinase

• School: University of Waterloo
• Department: Kinesiology
• Course: KIN217
• Professor: Monica Vesely

Document Summary

Gluconeogensis / pyruvate dehydrogenase: rbc and brain, how maintain blood glucose level above 2. 5mmol/l, diet, glycogen, gluconeogenesis (catabolic) Glucogenesis: ability to make glucose from noncarbo precursors (main source of gluc w/extended fasting) Liver is main gluconeogenic tissue (some also in kidney) Gluconeogenic pathway: pyruvate to glucose, reversal of glycolysis (same revers enz as glycolysis, requires 4 distincy enz (to counter 3 irr steps of glycolysis, main substrate for gluconeogenesis. In mammals (min of 3 c lactate, aa, glycerol triacyglycerol backbone: most occurs in cytoplasm, *functional groups. Irrever enz: glycolysis (first step, f6p, phosphoenolpyruvate, gluconeogenesis (g6ptase, f1 6tase, pyr carboxylase, phosphophenolpyruvate carboxykinase) Phosphoenolpyruvate carboxykinase: pepck decarboxylates and phosphorylates oxalaoacetate (gtp, decarboxylation reaction used to power the phosphorylation. Glucose production: fruc 1,6-b. tase = reciprocal enzyme of pfk, highly regulated irr step, need to examine regulation together, g6p. tase = enz mainly in liver.