KIN242 Lecture Notes - Lecture 6: Basal Ganglia, Hyperkinetic Disorder, Chorea
13 Mar 2017
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Document Summary
Increase in astrocytes due to loss of neurons. Recall: basal ganglia: voluntary movement, action selection. Earliest symptoms: primarily non- motor, decision making, attention impaired, short-term memory lapses, depression, changes in behaviour (irritability, aggressive, antisocial, minor motor changes, twitches, restlessness. Interferes with: walking: poor balance control (stagger, wide step width), frequent falling, speaking: slurred speech, swallowing. Primary motor symptoms: chorea (a dyskinesia: involuntary movement around multiple joints, brief, irregular movements, generally not repetitive or rhythmic, movements seem to flow randomly from one muscle to the next, can occur spontaneously or during attempts to move. Primary motor symptoms: ballism: chorea can progress to ballism, violent, flinging and involuntary movement. Primary motor symptoms: chorea is uncommon, bradykinesia more common, why, likely due to which striatal cells are affected first, d(cid:884): (cid:494)indirect(cid:495) pathway chorea, d(cid:883): (cid:494)direct(cid:495) pathway bradykinesia. Early motor resembles more like parkinson(cid:495)s because the direct loop is the one affected.
