Question: What are the underlying mechanism for muscle atrophy?
ANS: Apoptosis (highly conserved automated cell death)
Dysregulation in apoptosis is the cause for diseases
• Insufficient apoptosis results in undesirable tissue growth
• Too much apoptosis results in undesirable tissue dissipation
• Mitochondria regulates apoptosis
• One key feature in apoptosis is DNA fragmentation
Can Exercise alter apoptosis in muscle?
• Experiment with mice:
o 2 groups: Hypertensive BP and Normal BP
o randomized into Sedentary group (control) and Exerc