KIN404 Lecture 8: Section 2 Regulation of Energy Expenditure

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Kin 404 section 2 regulation of energy expenditure lecture 8. Hff increased resting soleus vo2 in both wt and sln-ko mice. Sln was elevated by 4x in wt mice in response to hff, and that was thought as the mechanism to protect them from obesity. Muscle vo2 was significantly increased in both wt and. In wt, sln is increased after hff and that explains the increase in muscle vo2. But, sln-ko does not have sln which means something else is burning calories after hff, and that leads to a higher resting muscle vo2. Whole body vo2 was lower in sln-ko mice after hff but not while asleep. The daily whole body vo2 is significantly lower in the sln-ko mice: this is why they are more obese although they don"t eat as much and have same level of activities as wt mice does.

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