KIN404 Lecture Notes - Lecture 7: Serca, Uncoupling Protein, Atp Hydrolysis
14 Feb 2019
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Kin 404 section 2 regulation of energy expenditure lecture 7. Sarcolipin is a serca pump regulatory protein that physically interacts with serca pump: serca pump efficiency energy expenditure, bind to serca pump near the ca2+ binding site and thus lowers the affinity of. Ca2+ binding site and inhibits the activities for serca pump: sln is also a serca pump uncoupling protein, uncouples the hydrolysis of. Atp from the accumulation of the calcium by ca2+-atpase of skeletal muscle sarcoplasmic reticulum: sln also increase heat production by ca2+-atpase. Sarcolipin uncouples hydrolysis of atp from accumulation of ca2+ by serca pumps. Sln = rate of ca2+ transport. Sln inhibits ca2+ transport by serca pumps. Rate of atp hydrolysis is not influenced by adding more. Ca2+ uptake is inhibited but the pump is still using atp. Produce more heat the energy released from atp hydrolysis (partially used to pump calcium and a large fraction is released as heat) energy to pump the calcium.
