BIOC 302 Lecture Notes - Lecture 3: Phosphoribosyl Pyrophosphate, Anomer, Ribose 5-Phosphate
Document Summary
In von gierke"s disease, overproduction of uric acid occurs. This disease is caused by a deficiency in g6p. Why does hypoglycemia occur in this disease liver cannot release glucose. Glucose gets trapped in the liver as glycogen and cannot be released. Outline the biochemical events leading to increased uric acid secretion glucose-6 phosphate leads to the pentose phosphate pathway = ribose-5 phosphate = purine synthesis = uric acid buildup. Leads to: ribose-5-phosphate what we are focusing on, nadph. Takes a nitrogenous base, puts it on ribose-5-phosphate. What comes out of the pool due to degradation: ribose-5-phosphate (which goes back into the de novo/salvage pathways, urea, nh3, carbon skeletons. Costs a net of 2 atp (generates amp) ** you don"t have to know the intermediate names or the enzymes that are not regulated** Prpp serves as your platform for purine synthesis: formation of 5-phospho- -d-ribosylamine.
