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Biol 121- 2010.03.03- Genetics- Gene Technology (Ch. 19).docx

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University of British Columbia
BIOL 121
Carol Pollock

Biol 121 225 Freeman 390395 407411 417424Mar 3 10Ch 19 Gene Technology Pituitary dwarfism and growth people with pituitary dwarfism have defective copies of the gene GH1 which hormone codes for the GH1 growth hormone protein affected people are typically no more than 4 feet tall by adulthoodgrowth hormone was injected into people just like insulin injections for diabetes only growth hormone from humans worked and therefore it had to be extracted from cadavers dead bodies and therefore was scarceexpensiveeven worse infectious proteins called prions that cause degenerative brain disorders emerged in patientspeople can get prions by inheritance or by eating prion proteins their growth hormone supply was contaminated with a prion protein from the brains of the cadavers supplying the hormone Retroviruses retroviruses are currently the vector of choice in gene therapy they are viruses that have an RNA genome and can code for proteins that produce DNA from their RNA and insert it into the DNA of the cellhowever viruses usually cause disease and even when inactivated altered particles may be able to recombine with viral DNA that already exists in the individual being treated and lead to the formation of a new infectious strain Method of introducing alleles into 1 Engineered retrovirus has recombinant RNA containing viral and human human cells using engineered viruses sequences 4 steps 2 Recombinant genes enter host cell 3 Viral enzymes make
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