BIOL 200 Lecture Notes - Lecture 7: Cdc25, Wee1, Proteasome

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10 Dec 2017
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If you get rid off it, you get through cell division faster. Not sufficient activating phosphatase (removal of inhibitory phosphate) If get rid of it, cell can"t divide (inhibitory phosphate will always be there) Inhibitory phosphate has to be removed and activating phosphate needs to be there to activate cdk. Additional control on cyclin to allow control of cell cycle progression. Phosphorylated and allows translation for mrna which activates s-cdk complex. Example 2: the more active the m-cdk is, the more it is able to phosphorylate. Two major things that happen during prophase: condensing of dna ( condensin , formation of mitotic spindle centrosomes duplicate and migrate to separate side of cell. Major difference: prometaphase have nuclear envelope degrading/breaking down. See slide for other characteristics of the two phases. Kinetochore : collection of proteins that bind to the centromere. Most stable associate: centrosome attached to 2 separate chromatids.

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